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References：Topliss, J.G.“A manual method for applying the Hansch approach to drug design.” J. Med. Chem.1977, 20,463-469.Hansch, C.;Fujita, T. “p-σ-π Analysis. AMethod for the Correlation of Biological Activity and Chemical Structure.” J. Am. Chem. Soc.1964, 86,1616-1626.Topliss, J.G. Utilization of operationalschemes for analog synthesis in drug design, J. Med Chem., 1972, 15, 1006-1011.